BioXolver
Until now, SAXS analysis of biological samples was largely restricted to synchrotron facilities or low-throughput lab setups that demanded large sample volumes and complex workflows.
The BioXolver overcomes these limitations with a groundbreaking approach, combining high-throughput capability, minimal sample consumption, and automated operation — all in a compact, lab-based instrument.
With BioXolver, structural biology SAXS becomes fast, accessible, and precise — directly from microliter volumes, without compromising on data quality.
High-Quality SAXS Data — Now in Your Lab
SAXS measurements that once required access to synchrotron facilities can now be performed routinely in the laboratory — with the BioXolver.
With BioXolver, you gain:
Publication-quality SAXS data — ideal for advanced modeling and structural analysis.
Precise determination of essential structural parameters such as radius of gyration (Rg), molecular weight, and particle dimensions.
Daily access to structural insights of proteins in solution — offering vital, complementary information to crystallography, NMR, and cryo-EM.
Optimized for Biological Samples
Biological macromolecules scatter weakly, demanding an instrument that maximizes signal and minimizes background noise.
The BioXolver delivers on both fronts with:
Maximized X-ray intensity via advanced beamline-inspired optics.
Ultra-low background detection, ensuring even subtle structural features are accurately captured.
Bring synchrotron-quality SAXS into your lab — compact, accessible, and precise.
In-line SEC and UV-Vis Combined with SAXS — Now Available in the Lab
Unlock deeper structural insights with in-line size-exclusion chromatography (SEC) and UV-Vis detection, seamlessly integrated with SAXS in the BioXolver system.
This powerful combination allows for:
Real-time structural characterization of proteins during elution.
Clean, monodisperse sample analysis by separating aggregates and impurities prior to SAXS measurement.
Structural investigation of heterogeneous or aggregation-prone multi-domain proteins, as well as dynamic protein complexes in equilibrium.
Whether working with small proteins or large assemblies, the BioXolver’s in-line SEC-SAXS-UV setup ensures precise, high-quality data — directly in your lab, no synchrotron required.