Structure determination of small and macromolecular molecules

The XtaLAB PRO series of single crystal diffractometers addresses a wide range of sample types, from small molecules to MOFs, to biological macromolecules. The key component that is common for this series of diffractometers is the use of a HPAD (hybrid pixel array detector) detector. HPAD technology produces an almost perfect detector and greatly expands the capabilities of a single crystal diffractometer in terms of speed of data acquisition and more accurate measurement of weak data. The standard detector in the XtaLAB PRO series is the PILATUS3 R 200K, which is well proven in the field and based on the same technology adopted by synchrotron beamlines around the world. The outstanding characteristics of these detectors ensure that every XtaLAB PRO diffractometer will produce the best data possible for the X-ray source selected.

XtaLAB PRO is optimized for data collection on both small and macromolecules. Single or dual source options are available, as well as custom configurations.

Why the HPAD detector?

There are basically four types of detectors currently being used with single crystal diffractometers: HPAD, CCD, CMOS and IP. The HPAD is the newest technology and is unique in that it is a photon counting detector that directly detects X-ray photons without the intermediate step of converting the photons to light with a phosphor.

The HPAD detector allows for shutterless data collection due to the extremely fast readout. In addition, the extremely low noise characteristics means that you can count poorly diffracting samples for a long period of time without swamping the signal with electronic noise. The combination of these features means that you will collect better data faster.

Choose Your X-ray Source

While the HPAD detector is the common element of the XtaLAB PRO series, the selection of X-ray sources is quite diverse and allows one to select an X-ray source configuration based on the radiation type or types as well as the level of flux desired. The standard configuration for the XtaLAB PRO includes a Cu MicroMax-003 microfocus sealed tube source and confocal optic. For samples that require higher flux, two rotating anode sources, the MicroMax-007 HF and FR-X, are available and offer a low-maintenance regimen compared to rotating anodes of the past. While the ongoing maintenance of a rotating anode generator is more than that of a sealed tube generator, the increase in flux at the sample is significantly higher and allows researcher to measure samples that could only previously be measured at a synchrotron.